Answer
In vitro, folylpolyglutamate synthetase converts pemetrexed to polyglutamate forms that are retained within cells, have longer intracellular half-lives and inhibit thymidylate synthase and glycinamide ribonucleotide formyltransferase more potently, thereby prolonging pemetrexed’s action in malignant cells.
Sources for this answer
- Pemetrexed Sandoz 25 mg/ml Concentrate for solution for infusionSandoz Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated
Sources checked