Answer
Co-trimoxazole may increase free methotrexate levels in plasma; if co-trimoxazole is considered appropriate during methotrexate treatment, a folate supplement should be considered.
Sources for this answer
- Co-trimoxazole 16mg/80mg per ml solution for infusionAspire Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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