Answer
Clarithromycin is a strong CYP3A4/P-gp inhibitor that significantly increases neratinib exposure, so concomitant use with Nerlynx (neratinib maleate) is not recommended; if clarithromycin cannot be avoided, the Nerlynx dose should be adjusted.
Sources for this answer
- Nerlynx 40 mg film-coated tabletsPierre Fabre Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 13Document updated
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