Answer
Cladribine is converted intracellularly to CdATP, which incorporates into DNA, blocking new DNA synthesis and inhibiting repair, causing DNA strand breaks and reduced NAD and ATP levels even in resting cells; CdATP also inhibits ribonucleotide reductase.
Sources for this answer
- LITAK 2mg/ml solution for injectionLIPOMED GmbH · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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