Answer
Cimetidine increases systemic exposure to varenicline tartrate by 29% by reducing its renal clearance; no dose adjustment is recommended with normal renal function or mild to moderate renal impairment, but concurrent use should be avoided in severe renal impairment.
Sources for this answer
- CHAMPIX 0.5 mg film-coated tablets; CHAMPIX 1 mg film-coated tabletsPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 46Document updated
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