chlorambucil · Medicine question

How does chlorambucil act on cancer cells?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Chlorambucil acts as a bifunctional alkylating agent, interfering with DNA replication and inducing programmed cell death through accumulation of cytosolic p53 and subsequent activation of Bax.

Sources for this answer

Chlorambucil 2mg tabletsAspen · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated 3 November 2015

Sources checked 8 November 2026

Explore this learning need in CPDTake this topic to CPD, then choose your learning context and available question library.

Are contraceptive precautions recommended when either partner is receiving chlorambucil?How common are convulsions in children with nephrotic syndrome receiving chlorambucil?How much lactose does each Leukeran (chlorambucil) 2 mg tablet contain?Is breastfeeding recommended during chlorambucil treatment?What common gastrointestinal side effects are listed for chlorambucil?What does the prescribing information say about chlorambucil use during pregnancy?

loading page…

Answer

Sources for this answer

More questions about chlorambucil

Answer

Sources for this answer

More questions about chlorambucil

chlorambucil

More clinical questions?