Answer
In Sinemet (carbidopa + levodopa), carbidopa inhibits peripheral dopa decarboxylase, preventing levodopa’s conversion to dopamine in the peripheral circulation so that a higher proportion of the levodopa dose reaches the brain.
Sources for this answer
- Sinemet 12.5mg/50mg, 10mg/100mg, 25mg/100mg and 25mg/250mg TabletsOrganon Pharma (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 24Document updated
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