Answer
Canagliflozin hemihydrate increases distal tubular sodium delivery by blocking SGLT2-dependent glucose and sodium reabsorption, thereby increasing tubuloglomerular feedback, which is associated with reduced intraglomerular pressure and decreased hyperfiltration in preclinical diabetes models and clinical studies.
Sources for this answer
- Invokana 100 mg film-coated tabletsA. Menarini Farmaceutica Internazionale SRL · emc · SmPC §5.1 Pharmacodynamic properties · Version 24Document updated
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