cabotegravir · Medicine question

How does cabotegravir block HIV replication?

iatroX medicinesPublished 8 November 2026

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Answer

Cabotegravir binds to the active site of HIV integrase, blocking the strand transfer step of retroviral DNA integration that is essential for the HIV replication cycle.

Sources for this answer

Vocabria 600 mg prolonged-release suspension for injectionViiV Healthcare UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated 31 October 2025

Sources checked 8 November 2026

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Does cabotegravir affect oral contraceptives containing ethinyl estradiol and levonorgestrel?Has liver toxicity been reported with cabotegravir (Vocabria) in people without pre-existing liver disease?How long can cabotegravir remain in the circulation after a Vocabria injection?How much polysorbate 20 is present in each 3 mL vial of cabotegravir (Vocabria) 600 mg prolonged-release suspension for injection?What does the product information say about using cabotegravir (Vocabria) injections during pregnancy?

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