Answer
Betahistine’s mechanism is only partly understood, but it acts as a partial histamine H1-receptor agonist and H3-receptor antagonist, with negligible H2 activity, increasing histamine turnover and release through presynaptic H3 blockade and H3-receptor downregulation.
Sources for this answer
- SERC - 8Viatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 12Document updated
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