apremilast · Medicine question

How does apremilast reduce inflammation?

iatroX medicinesPublished 8 November 2026

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Apremilast inhibits phosphodiesterase 4 (PDE4), increasing intracellular cyclic AMP, which reduces inflammatory responses by modulating pro-inflammatory cytokines and anti-inflammatory cytokines such as IL-10.

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Otezla 10mg, 20mg, 30mgAmgen Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 21Document updated 18 June 2026

Sources checked 8 November 2026

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