Answer
Andexanet alfa predominantly binds and sequesters factor Xa inhibitors; it also binds and inhibits tissue factor pathway inhibitor (TFPI), which can increase tissue factor-initiated thrombin generation and induce a pro-coagulant effect.
Sources for this answer
- Ondexxya 200 mg powder for solution for infusionAstraZeneca UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 17Document updated
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