Answer
Amiodarone decreases hepatic metabolism of lidocaine injection, potentially increasing lidocaine levels and neurological and cardiovascular toxicity; clinical monitoring, ECG and possibly plasma-level checks should be performed, with dosage monitoring if needed during and after amiodarone therapy.
Sources for this answer
- Lidocaine 10 mg/ml (1 % w/v) solution for injection in pre-filled syringeAguettant Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
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