Answer
Aciclovir sodium is phosphorylated in herpes-infected cells to active aciclovir triphosphate, initially dependent on HSV-coded thymidine kinase; the triphosphate inhibits and acts as a substrate for herpes-specific DNA polymerase, preventing further viral DNA synthesis without affecting normal cellular processes.
Sources for this answer
- Aciclovir 25 mg/ml Concentrate for Solution for InfusionHospira UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated
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