Answer
Abacavir increased mean methadone systemic clearance by 22% in a study using abacavir 600 mg twice daily; patients taking both medicines should be monitored for withdrawal symptoms, as methadone dose adjustment may occasionally be required.
Sources for this answer
- Ziagen 20 mg/ml Oral SolutionViiV Healthcare UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 52Document updated
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