Answer
In cinnarizine + dimenhydrinate, dimenhydrinate acts predominantly on the central vestibular system through antihistamine and anticholinergic effects, while cinnarizine acts predominantly on the peripheral vestibular system by inhibiting calcium influx into vestibular sensory cells.
Sources for this answer
- Cinnarizine/Dimenhydrinate 20 mg/40 mg tabletsBrown & Burk UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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