Answer
In Xultophy, insulin degludec activates insulin receptors, increasing muscle/fat glucose uptake and suppressing liver glucose output; liraglutide activates GLP-1 receptors, glucose-dependently increasing insulin and reducing excess glucagon, with a minor gastric-emptying delay, while during hypoglycaemia reducing insulin secretion without impairing glucagon secretion.
Sources for this answer
- Xultophy 100 units/mL + 3.6 mg/mL solution for injectionNovo Nordisk Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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