Answer
In olmesartan medoxomil/hydrochlorothiazide, olmesartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldosterone release, while hydrochlorothiazide increases renal sodium and chloride excretion, reducing plasma volume; its precise antihypertensive mechanism is not fully known, and the components have additive blood-pressure-lowering effects.
Sources for this answer
- Olmesartan/Hydrochlorothiazide 20 mg/12.5 mg film-coated tabletsThornton & Ross Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated
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