Answer
In Triumeq, dolutegravir binds HIV integrase’s active site and blocks DNA strand transfer, while abacavir and lamivudine are converted intracellularly to active triphosphates that competitively inhibit HIV reverse transcriptase, primarily acting through incorporation into viral DNA as monophosphates to terminate the chain.
Sources for this answer
- Triumeq 50 mg/600 mg/300 mg film-coated tabletsViiV Healthcare UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 33Document updated
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