Answer
In Delstrigo, doravirine non-competitively inhibits HIV-1 reverse transcriptase, lamivudine’s active triphosphate terminates DNA chains after incorporation, and tenofovir disoproxil, converted to tenofovir diphosphate, competes with deoxyadenosine triphosphate for reverse transcriptase and terminates DNA chains after incorporation.
Sources for this answer
- Delstrigo 100 mg /300 mg /245 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated
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