Answer
In Biktarvy, bictegravir binds HIV integrase’s active site and blocks DNA strand transfer, while emtricitabine and tenofovir alafenamide become emtricitabine triphosphate and tenofovir diphosphate, respectively, which HIV reverse transcriptase incorporates into viral DNA, terminating DNA chains.
Sources for this answer
- Biktarvy 50 mg/200 mg/25 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 21Document updated
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