How do the ibuprofen and paracetamol components of ibuprofen + paracetamol act to relieve pain?

In Nuromol (ibuprofen + paracetamol), ibuprofen inhibits peripheral COX-2 and prostaglandin synthesis, reducing pain-nerve sensitisation, with spinal COX inhibition also contributing, while paracetamol’s incompletely understood action likely involves central COX-2 inhibition and possibly descending serotonin pathways, producing synergistic pain relief.