Answer
In Emtricitabine/Rilpivirine/Tenofovir Disoproxil Gilead, tenofovir disoproxil becomes tenofovir, then cellular phosphorylation produces tenofovir diphosphate and emtricitabine triphosphate, which competitively inhibit HIV-1 reverse transcriptase and terminate DNA chains, while rilpivirine inhibits the enzyme non-competitively.
Sources for this answer
- Emtricitabine/Rilpivirine/Tenofovir Disoproxil Gilead 200 mg/25 mg/245 mg film coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 33Document updated
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