Answer
In Emtricitabine/Rilpivirine/Tenofovir Alafenamide Gilead, emtricitabine triphosphate competitively inhibits HIV-1 reverse transcriptase, rilpivirine inhibits it non-competitively, and tenofovir alafenamide's active metabolite, tenofovir diphosphate, inhibits HIV reverse transcriptase, with emtricitabine and tenofovir metabolites causing DNA chain termination.
Sources for this answer
- Emtricitabine/Rilpivirine/Tenofovir Alafenamide Gilead 200 mg/25 mg/25 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 24Document updated
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