Answer
In efavirenz/emtricitabine/tenofovir disoproxil maleate, efavirenz non-competitively inhibits HIV-1 reverse transcriptase, while cellular phosphorylation of emtricitabine and tenofovir (formed from tenofovir disoproxil) produces emtricitabine triphosphate and tenofovir diphosphate, which competitively inhibit the enzyme, terminating DNA chains.
Sources for this answer
- Efavirenz/Emtricitabine/Tenofovir Disoproxil 600 mg/200 mg/245 mg Film-coated TabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 17Document updated
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