Answer
In Lecigon, carbidopa inhibits peripheral dopa decarboxylase, reducing levodopa conversion to dopamine and increasing its availability to the brain, while entacapone inhibits mainly peripheral COMT, reducing levodopa clearance and prolonging its clinical response.
Sources for this answer
- Lecigon 20 mg/ml + 5 mg/ml + 20 mg/ml intestinal gelBritannia Pharmaceuticals Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated
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