How do antacids containing magnesium hydroxide and aluminium hydroxide affect the absorption of febuxostat magnesium?

For Elstabya (febuxostat magnesium), concomitant antacids containing magnesium hydroxide and aluminium hydroxide delay absorption by approximately one hour and decrease peak concentration (Cmax) by 32%, without significantly changing overall exposure (AUC), so Elstabya may be taken without regard to antacid use.