Answer
Abacavir and lamivudine in Kivexa are converted intracellularly to active triphosphates that competitively inhibit HIV reverse transcriptase, but their main antiviral action is incorporation of their monophosphate forms into viral DNA, causing chain termination.
Sources for this answer
- Kivexa 600 mg/300 mg film-coated tabletsViiV Healthcare UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 43Document updated
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