How can tricyclic antidepressants affect skin-prick testing with histamine dihydrochloride (Soluprick Positive Control)?

Tricyclic antidepressants may suppress the response to Soluprick Positive Control (histamine dihydrochloride) through an antihistamine-like effect, potentially causing false-negative results, so results require cautious interpretation and consideration of the antidepressant’s elimination time in its product information.