How can the fluconazole in Canesten Thrush Duo interact with warfarin?

Fluconazole in Canesten Thrush Duo can prolong prothrombin time up to twofold with warfarin, probably by inhibiting CYP2C9-mediated metabolism, with reported bleeding; careful prothrombin-time monitoring and possible warfarin dose adjustment are needed, while single-dose effects are hard to predict and enzyme inhibition persists 4–5 days after stopping fluconazole.