How can sevelamer hydrochloride affect ciclosporin, mycophenolate mofetil and tacrolimus levels in transplant patients?

With Renagel (sevelamer hydrochloride), reduced ciclosporin, mycophenolate mofetil and tacrolimus levels have been reported in transplant patients without clinical consequences such as graft rejection; an interaction cannot be excluded, so close blood concentration monitoring should be considered during combined use and after withdrawal.