Answer
Sarilumab may reverse IL-6’s inhibitory effect and restore CYP3A4 activity, decreasing exposure to and activity of statins that are CYP3A4 substrates, so caution is advised when starting sarilumab in patients taking these statins.
Sources for this answer
- Kevzara 150 mg solution for injection in pre-filled penSANOFI · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated
Sources checked