Answer
Ritonavir or itraconazole can inhibit CYP3A4-mediated corticosteroid metabolism, increasing systemic exposure to betamethasone valerate in betamethasone valerate + clioquinol; clinical relevance depends on the corticosteroid dose and administration route and the CYP3A4 inhibitor’s potency.
Sources for this answer
- Betamethasone valerate/Clioquinol 1 mg/30 mg/g OintmentChemidex Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
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