Answer
Proton pump inhibitors inhibit organic anion transporter 3 (OAT3) and delay pemetrexed clearance when used concomitantly, so the combination requires caution.
Sources for this answer
- Pemetrexed SUN 100 mg powder for concentrate for solution for infusionRanbaxy (UK) Limited a Sun Pharmaceutical Company · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
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