Answer
Oxcarbazepine and its active metabolite MHD can lower ciclosporin and tacrolimus plasma concentrations by weakly inducing CYP3A4 and CYP3A5, enzymes responsible for their metabolism.
Sources for this answer
- Trileptal 150 mg, 300 mg, 600 mg Film-coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 32Document updated
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