Answer
Nonsteroidal anti-inflammatory drugs can reduce acebutolol’s blood-pressure-lowering effect by inhibiting vasodilator prostaglandins, with phenylbutazone also causing fluid retention.
Sources for this answer
- Acebutolol 400 mg film-coated tabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
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