Answer
Metoclopramide can reduce the therapeutic effect of levodopa in Duodopa, so patients taking both should be carefully monitored for loss of therapeutic response; this interaction is known from levodopa/carbidopa, as no interaction studies have been performed with Duodopa.
Sources for this answer
- Duodopa intestinal gelAbbVie Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 22Document updated
Sources checked