Answer
Metformin is cleared by the kidneys and can accumulate if kidney function worsens, increasing the risk of lactic acidosis. Kidney function therefore requires assessment before and during treatment.
Sources for this answer
- Competact 15 mg/850 mg film coated tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.