Answer
Ketoconazole or fluconazole may increase systemic exposure to tapentadol by strongly inhibiting UGT enzymes involved in its principal elimination pathway, conjugation with glucuronic acid.
Sources for this answer
- Tapentadol Krka 150 mg prolonged-release tabletsKrka UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
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