Answer
Based on studies of the individual component rather than dutasteride + tamsulosin together, ketoconazole, a strong CYP3A4 inhibitor, increased tamsulosin hydrochloride peak concentration (Cmax) 2.2-fold and total exposure (AUC) 2.8-fold.
Sources for this answer
- Combodart 0.5 mg / 0.4 mg hard capsulesGlaxoSmithKline UK · emc · SmPC §4.5 Interaction with other medicinal products · Version 15Document updated
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