Answer
Ketoconazole, a strong CYP3A4 inhibitor, may increase blood concentrations of temsirolimus and its active metabolite sirolimus, so concomitant treatment should be avoided.
Sources for this answer
- TORISEL 30 mg concentrate and solvent for solution for infusionPfizer Limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 33Document updated
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