Answer
Ketoconazole inhibits CYP3A4 and may increase fentanyl bioavailability by decreasing its systemic clearance, potentially enhancing or prolonging Abstral (fentanyl citrate)'s opioid effects, so concomitant use requires caution.
Sources for this answer
- Abstral Sublingual TabletsGrunenthal Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated
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