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Medicines indometacinQuestion & answer

indometacin · Medicine question

How can indometacin increase methotrexate toxicity?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Indometacin has been reported to decrease methotrexate's tubular secretion and potentiate its toxicity, so simultaneous use requires caution.

Sources for this answer

Indometacin 100mg suppositoriesAspen · emc · SmPC §4.5 Interaction with other medicinal products · Version 6Document updated 31 August 2022

Sources checked 8 November 2026

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indometacin

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