Answer
Disodium levofolinate may diminish the antiepileptic effects of phenobarbital, primidone, phenytoin or succinimides and increase seizure frequency, potentially through increased hepatic metabolism and reduced anticonvulsant plasma levels.
Sources for this answer
- Levofolinic acid 50 mg/ml Solution for injection or infusionmedac Pharma LLP · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated
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