Answer
Cimetidine inhibits OCT2 and may reduce kidney elimination of metformin in Jentadueto (linagliptin + metformin), increasing metformin blood concentrations; caution is advised, especially with renal impairment, and metformin dose adjustment may be considered.
Sources for this answer
- Jentadueto 2.5 mg/850 mg and 2.5 mg/1,000 mg film-coated tabletsBoehringer Ingelheim Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 24Document updated
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