How can ceftriaxone sodium affect the action of oral anticoagulants?

Name: How can ceftriaxone sodium affect the action of oral anticoagulants?
Published: 2026-11-08T13:42:20.438Z

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Ceftriaxone sodium may increase oral anticoagulants’ anti-vitamin K effect and bleeding risk, so INR should be monitored frequently and the anti-vitamin K drug dose adjusted accordingly during and after ceftriaxone treatment.

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Rocephin 250mg Powder for Solution for Injection, 1g Powder for Solution for Injection or Infusion, 2g Powder for Solution for Injection/InfusionRoche Products Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 27Document updated 15 January 2025

Sources checked 8 November 2026

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