Answer
Amantadine taken concurrently may enhance the antimuscarinic effects of orphenadrine hydrochloride, potentially causing severe constipation and ileus, atropine-like psychoses, or heat stroke, although additional effects may be minor.
Sources for this answer
- Orphenadrine Hydrochloride 50mg/5ml Oral SolutionRosemont Pharmaceuticals Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated
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