How are lidocaine and prilocaine metabolised and eliminated after application of EMLA Cream?

After EMLA Cream application, lidocaine and prilocaine are mainly metabolised in the liver and their metabolites excreted renally; absorption governs metabolism and elimination rates, so reduced clearance, including severe liver impairment, has limited effects on plasma concentrations after a single dose or once-daily doses for up to 10 days.