Answer
Trametinib alone is not expected to reduce hormonal contraceptive efficacy, but accompanying dabrafenib may do so. The specialist team should advise an effective alternative method.
Sources for this answer
- Mekinist film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- Spexotras 0.05 mg/ml powder for oral solution — Current selected SmPCemc · Summary of Product Characteristics