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Medicines macitentanQuestion & answer

macitentan · Medicine question

Does St John's wort interact with macitentan?

iatroX medicinesPublished 21 August 2026Reviewed 21 August 2026

The answer

Answer

Yes. It can reduce macitentan exposure and effectiveness, so the combination should be avoided.

Sources for this answer

Opsumit 10mg film coated tablets (Great Britain)emc · SmPC Current selected SmPC · Version 28

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The full medicine guide

macitentan

Read the wider context, including uses, precautions and the sources behind this medicine guide.

Read the macitentan guide

More questions about macitentan

What is macitentan used for?How does macitentan help pulmonary arterial hypertension?Can macitentan be taken with food?Can film-coated tablets be crushed or split?How are dispersible tablets prepared?Why are blood tests needed?

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